Drug Invention – MDMA or Ecstacy
The invention of love drug MDMA otherwise known as “Ecstacy”
MDMA is an entactogenic drug of the phenethylamine and amphetamine class of drugs. It is a colorless oil that boils at around 155 degrees Celsius or 311 degrees Fahrenheit. In chemical parlance, MDMA is referred to as MDMA (3,4-Methylenedioxymethamphetamine) or Methylenedioxymethamphetamine.
In popular culture, MDMA has become widely known as “ecstasy” (“E” or “X”), usually referring to its street pill form. The terms “molly” or “mandy” (“M”) can colloquially refer to MDMA in crystalline or powder form.
Effects of MDMA or Ecstacy
MDMA can induce euphoria, a sense of intimacy with others, and reduced anxiety. Many studies have suggested that MDMA has therapeutic benefits. Clinical trials are testing its therapeutic potential for post-traumatic stress disorder (PTSD) and anxiety associated with terminal cancer.
Legal Implications of MDMA
MDMA drug has been criminalized in most countries under a United Nations agreement, and its possession, sale, or manufacture may result in criminal prosecution, although limited exceptions exist for scientific and medical research. Regulatory authorities in some locations around the world have approved scientific studies administering MDMA to humans, in particular, to examine its therapeutic potential and its effects.
History of MDMA or Ecstacy
MDMA was first synthesized in 1912 by a Merck chemist Anton Köllisch. During that time, Merck was interested in developing substances that stopped abnormal bleeding. On directives from his superiors Walther Beck and Otto Wolfes, Köllisch developed a preparation of a hydrastinine analogue, methylhydrastinine. MDMA is an intermediate compound in the synthesis of methylhydrastinine.
At that time Merck was not interested in MDMA’s properties, but on December 24, 1912, Merck filed two patent applications that described the synthesis of MDMA and its subsequent conversion to methylhydrastinine.
MDMA’s history is clouded in mystery, with some unknown development facts. Köllisch died in World War I, however, further research and experiments of MDMA have been done in more recent years. The best known work is by biochemist Alexander Shulgin. After graduating with a Ph.D. in biochemistry from the university of California at Berkeley, he took a job as research chemist with Dow Chemicals. Among his achievements for the company was a profitable insecticide and several controversial for what were to become later as street drugs.
Although MDMA has been used as treatment for patients in some areas of psychotherapy, it is best known of its untoward impact on its illegal drug implications.
Sources and Further Readings:
- MDMA (ECSTACY) Fast Facts - www.justice.gov
- MDMA – en.wikipedia.org
- NIDA Institute on Drug Abuse – NIDA Infofacts: MDMA (Ecstacy)
- The Invention of MDMA or Ecstacy - inventors.about.com
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Bill Gates and The Road Ahead
This post is revisited to remember the birthday of Bill Gates, October 28.
Bill Gates: Microsoft Co-Founder, Technologist, Business Magnate, Philanthropist
A Quote from Gates’ old book The Road Ahead
One of the books written by Microsoft’s co-founder, Bill Gates, that has inspired me and most likely a lot of information technology folks out there, is one of his earliest books, The Road Ahead. I was then an IBMer when I got hold of this motivating book. Somehow, I never forgot his message about ‘failure’ – or – on the positive note, forging the road ahead.
I’m quoting Gates, which I think is appropriate, as we occasionally psyche our minds especially when our careers seem stymied or in a slump.
Mr. Gates said:
“When I was nineteen I caught a look at the future, based my career on what I saw, and I turned out to have been right. But the Bill Gates of nineteen was in a very different position from the one I’m in now. In those days, not only did I have all the self-assurance of a smart teenager, but also nobody was watching me, and if I failed – so what? Today, I am much more in the position of the computer giants of the seventies, but I hope I’ve learned some lessons from them.”
~ Bill Gates, American co-founder of Microsoft Corporation, philanthropist, business magnate. The Road Ahead, Viking Penguin, New York, 1995.
Bill Gates is a leftie, didn’t you know? — Lefty Bill Gates
This post was originally written June 15, 2011.
Post updated October 28, 2011
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Cars History
History of the Automobile at a Glance.
On the road there are now more than half a billion cars worldwide, and perhaps, two or three ones are built every second. There is an enormous variety of motor transport to all kinds of vehicles that can be driven, and motorbikes that can reach great speeds. However, all need brakes, driven by an engine (or motor) and most need gears to control the car’s engine.
The Early Automobiles
The first petrol-powered automobile was made in 1885 by German engineer Karl Benz, who developed his own version of the petrol engine and used it to power a three-wheeled carriage.

1885 Three-Wheeled Benz Patent Motorwagen
The prototype of today’s car was developed in France by René Panhard and Émile Lavassor in 1891, when they mounted a Gottlieb Daimler petrol engine in the front of their vehicle.
Until 1898, when Louis Renault invented the drive shaft, engine power was transferred to the drive wheels via a chain, as on bicycles.
Early 20th Century
During the first decade of the 20th century, cars evolved from motorized versions of the carriages previously driven by horses. The basic layout of the modern car was set on by which the engine is in the front of a four wheeled machine and all the passengers facing forwards. Later, the pressed-steel body made cars stronger and easier to produce were introduced.
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Ford Model T
In 1908, the first type of car to sell more than 1 million was the Model T Ford. Determined to corner the market and to produce cars that people can afford, Henry Ford adapted and improved the mass-production method pioneered by Ransom Eli Olds (1864–1950), pioneer of the American automotive industry for whom both the Oldsmobile and REO brands were named. Parts were manufactured in separate workshops and wheeled into the main factory so that workers can put the cars together. It took just over 12 hours to build each car.
Henry Ford and Mass-Production to Building Cars
From 1910, Henry Ford’s company applied mass production to car building. He saved money by having materials in bulk and cut production time by giving employees just one task to perform as the cars moved swiftly through the factory. Soon other manufacturers copied his techniques cutting the cost of new cars, and making it easier for people to buy their own.
The Smart Car Developed by Mercedes-Benz and Swatch
The Smart Car developed by Swatch and Mercedes-Benz is a two-seater designed for use in crowded cities, handy to be parked in a narrow street, and with hardly obstruction to traffic. Also, it has an economical engine and easily replaceable body panels. Its sale in Europe began in 1998.
Advances in Car Safety
As the number of road deaths became a public concern, by the 1970s, advances in car safety were developed to protect passengers. Seat belts, air bags, safety cages and crumple zones that absorb the energy of a crash were all introduced. Technology has it that traction control and anti-lock brakes were put in place to reduce likely accidents.
The Nissan Leaf is an all-electric launched in Dec 2010
Cars History Timeline
1769 – French engineer and mechanic Nicholas Joseph Cugnot builds a steam-powered tractor.
1789 – The first U.S. patent for a steam-powered land vehicle was granted to Oliver Evans.
1801 – A road carriage was built by Richard Trevithick. It was powered by steam.
1807 – François Isaac de Rivaz of Switzerland invented an internal combustion engine that used a mixture of hydrogen and oxygen for fuel.
1816 – John McAdam makes cambered roads of stone blocks with gravel in between.
1823 – Samuel Brown invents an internal combustion engine with separate combustion and working cylinders, used to power a vehicle.
1832-1839 – Scottish inventor Robert Anderson invented the first crude electric-powered carriage. The exact year is uncertain.
1860 – Etienne Lenoir introduces engines powered by coal gas.
1863 – Lenoir takes his automobile for the first drive.
1876- The four-stroke internal-combustion engine is assembled by Nikolaus Otto.
1885 – The first practical car is developed by Karl Benz.
1893 – Karl Benz mass produces the ideal car.
1903 – Henry Ford begins to manufacture automobiles.
1908 – The first Model T Ford comes off the production line.
1912 – A British company builds the first car with a steel body.
1929 – General Motors introduces synchromesh transmission.
1937 – The Volksvagen Beetle is launched in Germany.
1940s – Snowmobiles was introduced by Joseph Bombardier.
1959 – The Mini is launched by the British Motor Corporation
1974 – American scientist Victor Wouk fits a Buick Skylark with a hybrid engine.
1970s – Unleaded petrol is introduced to reduce air pollution by lead.
Readers may also want to read this related article: History of Motorsport Car Race and Car Rally
Today’s cars include numerous models and makes – classic cars, supercars, and everyday cars:
- ABT
- AC Schnitzer
- Acura
- Alfa Romeo
- Alpina
- Artega
- Ascari
- Aston Martin
- Audi
- BMW
- Bentley
- Bertone
- Brabus
- Breckland
- Bugatti
- Buick
- Cadillac
- Caparo
- Carlsson
- Caterham
- Chevrolet
- Chrysler
- Citroen
- Covini
- Dacia
- Daewoo
- Daihatsu
- Daimler
- De Tomaso
- Devon
- Dodge
- Donkervoort
- EDAG
- Edo
- Elfin
- Eterniti
- FM Auto
- FPV
- Farbio
- Ferrari
- Fiat
- Fisker
- Ford
- GM
- GMC
- Gordon Murray
- Gumpert
- HSV
- Hamann
- Hennessey
- Holden
- Honda
- Hummer
- Hyundai
- Infiniti
- Isuzu
- Italdesign
- Iveco
- Jaguar
- Jeep
- KTM
- Kia
- Kleemann
- Koenigsegg
- LCC
- Lada
- Lamborghini
- Lancia
- Land Rover
- Leblanc
- Lexus
- Lincoln
- Lobini
- Loremo
- Lotus
- MG
- Mansory
- Marcos
- Maserati
- Maybach
- Mazda
- Mazel
- McLaren
- Mercedes-Benz
- Mercury
- Mindset
- Mini
- Mitsubishi
- Mitsuoka
- Morgan
- Nismo
- Nissan
- Noble
- ORCA
- Oldsmobile
- Opel
- PGO
- Pagani
- Panoz
- Peugeot
- Pininfarina
- Plymouth
- Pontiac
- Porsche
- Proton
- Renault
- Rinspeed
- Rolls-Royce
- Rover
- Saab
- Saleen
- Saturn
- Scion
- Seat
- Singer
- Skoda
- Smart
- Spada
- Spyker
- SsangYong
- Startech
- Stola
- Strosek
- StudioTorino
- Subaru
- Suzuki
- TVR
- TechArt
- Tesla
- Think
- Toyota
- Tramontana
- Valmet
- Vauxhall
- Venturi
- Volkswagen
- Volvo
- Wald
- Wiesmann
- Yes
- Zagato
- Zenvo
Sources:
- Ellyard, David. Great Inventions of our Time. Sydney: New Holland (2007).
- Science and Technology Year by Year. The Five Mile Press (2001).
- www.netcarshow.com for list of car models. Accessed October 25, 2011
Image Source:
Wikimedia Commons
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George Westinghouse – Engineer and Inventor
George Westinghouse (1846-1914)
American Engineer and Inventor
George Westinghouse, Jr. (October 6, 1846 – March 12, 1914) was an American engineer and entrepreneur who invented the railway air brake and was a pioneer of the electrical industry. He was also one of Thomas Alva Edison‘s rivals in the early implementation of the American electricity system. Westinghouse’s system, which used alternating current based on the extensive research by Nikola Tesla, eventually prevailed over Edison’s insistence on direct Current.
In 1911, Westinghouse received the AIEE’s Edison Medal “For meritorious achievement in connection with the development of the alternating current system.”
Westinghouse Early Years Profile
Born in Central Bridge, New York, he ran away from school to fight for the North in the American Civil War, then served for a short time in the US Navy. He returned in 1865 to work in his father’s farm machinery workshop. It was also this time that he took out the first of his more than 400 patents, in particular, for a railway steam locomotive.
Westinghouse Important Inventions
His most important invention was the air-brake system he patented in 1869. This became known as “Westinghouse air brake” that greatly increased the speed of trains that could also travel safely.
Westinghouse also became a pioneer in the use of alternating current for electric power distribution. In 1886, he founded the Westinghouse Electrical Company, attracting Nicola Tesla to work with him. Nine year later, Westinghouse harnessed the power of the Niagara Falls to generate successfully enough electricity for the town of Buffalo.
Sources:
- Garbedian, H Gordon. George Westinghouse: A fabulous Inventor. (1943).
- George Westinghouse. IEEE Global History Network. IEEE. Accessed October 10, 2011.
- www.westinghousenuclear.com/Our_Company/history/george_westinghouse. Accessed October 10, 2011.
- web.mit.edu/invent/iow/westinghouse. Accessed October 10, 2011.







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